Computer-Aided Drug Resistance Calculator (US11227669B2): The Patent

Type: Patent

Publisher: USPTO

Year Published: 2015

Patent No: 11227669

Summary:

In seconds (not minutes), over 1.3 million computations and 320 plots of Spectral features were churned out from a 99 amino acids length of the HIV-1 Protease enzyme using 292 mutants, 22 Amino Acids Parameters and a patented FFT-based device called Computer-Aided Drug Resistance Calculator (US11227669B2). This is in an attempt to make a life-saving decision on the best medication(s) for a patient within a limited time by a Physician. These computed results aligned with the recorded biological responses. Resistant mutants demonstrated reduced susceptibility while the random sequences displayed erratic responses as a mark of sensitivity.

This patent introduces the Computer‑Aided Drug Resistance Calculator (CADRC), a point‑of‑care diagnostic device designed to analyze biological sequences using transparent, stepwise computation. It establishes the foundational hardware and conceptual framework that later evolved into the CADRC‑Initiative’s digital signal (FFT)–based modeling platform.

This study formed the basis of the initiative. You can read more of the invention [https://www.freepatentsonline.com/11227669.pdf]